Macrorealism formalizes the intuitive notion that at any given time the system occupies a definite state and that the evolution of the system is independent of the measurements performed on it, in contrast to the principles of quantum mechanics. In this study, we carry out a comparative analysis between Leggett-Garg-type inequalities and the conditions of no-signaling-in-time and arrow-of-time for macrorealism within the context of meson oscillations. Our findings indicate that, under given initial conditions, no violations of Leggett-Garg inequalities are observed. However, no-signaling-in-time conditions are found to be violated, thereby revealing the impossibility of applying a macrorealistic description to the analysis of meson physics.